c.365: Residence of Procopius before he decided to revolt
Bishop Basil establishes ecclesiastic center in the mortheastern part of the city, which in the Middle Ages woud supplant the ancient city center: orphanage, hospital for lwpers, almshouses, houses for the elderly
The circle of scholars around Saint Macrina, which included her brothers Basil the Great and Gregory Nazianzus together with Gregory of Nyssa, is usually called the "Cappadocian fathers". They played an important role in the discussions on the Trinity.